Nitoman (Tetrabenazine)
Generic Nitoman (Tetrabenazine) reduces the amount of certain chemicals in the body that are overly active in people with Huntington's disease.Generic Nitoman (Tetrabenazine) is used to treat Huntington's chorea (uncontrolled muscle movements).Generic Nitoman (Tetrabenazine) may also be used for other purposes not listed in this medication guide.
Nitoman (Tetrabenazine) Information
You should not use this medication if you are allergic to Generic Nitoman (Tetrabenazine), or if you have severe or untreated depression, suicidal thoughts, liver disease, or past or present breast cancer. Do not use Generic Nitoman (Tetrabenazine) if you have taken reserpine within the past 20 days, or if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) within the past 14 days. Before you take Generic Nitoman (Tetrabenazine), tell your doctor if you have heart disease, a personal or family history of "Long QT syndrome," or a history of depression or suicidal thoughts or actions.Generic Nitoman (Tetrabenazine) can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. You may feel depressed or have thoughts about suicide when you first start taking this medication. Your doctor will need to check you at regular visits during treatment.Stop taking Generic Nitoman (Tetrabenazine) and call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, confusion, trouble swallowing, uncontrolled muscle movements, extreme drowsiness, or if you feel restless, agitated, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.
Nitoman (Tetrabenazine) Uses
Tetrabenazine is used as a treatment, but not as a cure, for hyperkinetic disorders such as:
Huntington's disease specifically, the chorea associated with it
Tourette syndrome and other tic disorders
Tardive dyskinesia a serious and sometimes irreversible side effect of long-term use of many antipsychotics, mainly typical antipsychotics
Hemiballismus, spontaneous flinging limb movements due to contra-lateral subthalamic nucleus damage.
Huntington's disease specifically, the chorea associated with it
Tourette syndrome and other tic disorders
Tardive dyskinesia a serious and sometimes irreversible side effect of long-term use of many antipsychotics, mainly typical antipsychotics
Hemiballismus, spontaneous flinging limb movements due to contra-lateral subthalamic nucleus damage.
Nitoman (Tetrabenazine) Warnings
There is a boxed warning associated with the use of tetrabenazine
Increases the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease
Balance risks of depression and suicidality with the clinical need for control of chorea when considering the use of tetrabenazine
Monitor patients for emergence or worsening of depression, suicidality or unusual changes in behavior
Inform patients, caregivers and families of the risk of depression and suicidality and instruct to report behaviours of concern promptly to the treating physician
Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation
Tetrabenazine is contraindicated in patients who are actively suicidal and in patients with untreated or inadequately treated depression
Increases the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease
Balance risks of depression and suicidality with the clinical need for control of chorea when considering the use of tetrabenazine
Monitor patients for emergence or worsening of depression, suicidality or unusual changes in behavior
Inform patients, caregivers and families of the risk of depression and suicidality and instruct to report behaviours of concern promptly to the treating physician
Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation
Tetrabenazine is contraindicated in patients who are actively suicidal and in patients with untreated or inadequately treated depression
Nitoman (Tetrabenazine) missed dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Nitoman (Tetrabenazine) overdose
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea and vomiting, diarrhea, sweating, confusion, hallucinations, tremors, and restless muscle movements in your eyes, tongue, jaw, or neck.
Nitoman (Tetrabenazine) Side Effects
The most common adverse reactions, which have occurred in at least 10% of subjects in studies and at least 5% greater than in subjects who received placebo, have been: sedation or somnolence, fatigue, insomnia, depression, suicidal thoughts, akathisia, anxiety and nausea.
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